Extended Data Fig. 6: Schematic summary of PE-eVLP designs. | Nature Biotechnology

Extended Data Fig. 6: Schematic summary of PE-eVLP designs.

From: Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Extended Data Fig. 6

Schematic of accessory proteins, cargo proteins, guide RNA designs, and description of improvements from the previous version for successive generations of PE-eVLPs. Envelope protein VSV-G, and capsid protein MMLV Gag–Pol that are common in all versions of PE-eVLPs are omitted from the table. Schematics shown in the table represent PE2-eVLPs. For PE3-eVLPs, additional ngRNAs are packaged at a ratio of 4:1 for pegRNAs and ngRNAs with corresponding scaffold modification and aptamer insertion.

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