Extended Data Fig. 10: Off-target analysis in rd12 mice. | Nature Biotechnology

Extended Data Fig. 10: Off-target analysis in rd12 mice.

From: Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Extended Data Fig. 10

a, Analysis of PE-dependent editing at the on-target site and at the top 10 CIRCLE-seq nominated off-target sites associated with the rd12 epegRNA sequence. b, Analysis of indels at the on-target site and the top 10 CIRCLE-seq nominated off-target sites associated with the rd12 ngRNA sequence. Bars represent average values for n = 3 (untreated) or n = 3 (v3 PE3b-eVLP-treated), with each dot representing an individual mouse and error bars representing standard deviation.

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