Fig. 4: CNS editing with PE-eVLPs via P0 ICV injection. | Nature Biotechnology

Fig. 4: CNS editing with PE-eVLPs via P0 ICV injection.

From: Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Fig. 4

a, Schematic of workflow for neonatal ICV injection and subsequent analysis. FACS, fluorescence-activated cell sorting. b, Prime editing efficiency in bulk or GFP-positive population from the brain cortex collected 3 weeks following P0 ICV injection targeting the Dnmt1 locus with v3 PE3-eVLPs and v3b PE3-eVLPs. Bars represent the average prime editing efficiency of three mice and error bars represent the standard deviation, with each dot representing an individual mouse. Each mouse received approximately 1.0 × 1011 eVLPs in total.

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