Extended Data Fig. 7: Reversal of thrombin inhibition with an 8 mer PNA antidote. | Nature Biotechnology

Extended Data Fig. 7: Reversal of thrombin inhibition with an 8 mer PNA antidote.

From: Development of supramolecular anticoagulants with on-demand reversibility

Extended Data Fig. 7

a. Schematic representation of antidote addition and reversal of inhibition. b. Fluorogenic assay data showing the reversal of thrombin inhibition by addition of different concentrations of antidote (AD1) after 30 minutes of inhibition. c. Calibrated Automated Thrombogram (CAT) of A1-E1 with and without antidote (AD1). For data presented in b., and c., n = 3 replicates with individual data points presented as mean values +/− SD.

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