Extended Data Fig. 5: Additional Assays.
From: Development of supramolecular anticoagulants with on-demand reversibility
a. Fibrinogen inhibition assay of compounds A1-E1 and A1 and E1 alone. b. In vitro aPTT of A1-E1 in human (top) and mouse (bottom) plasma. n = 2 with both replicates displayed. c. Ex-vivo aPTT of A1-E1 at 0.314 μmol/kg (2.5 mg/kg) and 0.627 μmol/kg (5 mg/kg) versus Argatroban at 1.966 μmol/kg (1 mg/kg). For data presented in a., and c., n = 3 replicates with individual data points presented as mean values +/− SD.
