Fig. 4: Validation of COMPSS against enzymes generated from six previously unseen protein families and two new models.
From: Computational scoring and experimental evaluation of enzymes generated by neural networks
a, ESM-1v and ProteinMPNN scores of generated enzymes from the six families. The vertical dashed gray line indicates the top 10th percentile cutoff for ESM-1v score calculated from natural sequences from the same families. b, Proportion of active enzymes stratified by family and whether they passed the COMPSS sequence filter. c, COMPSS performance of the six families from publicly available data.
