Extended Data Fig. 3: Global and specific analyses of quantitative drug-induced protein expression changes.
From: Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics
a) List of all drugs ranked by the median potency (expressed as pEC50 = −log10 EC50) with which they regulated protein expression in Jurkat cells. b) Examples of dose-response curves of proteins from cells treated with the HSP90 inhibitor geldanamycin. c) Pie chart showing the proportion of all drug targets which are detected in the dataset. d) Examples of dose-response curves for drugs that regulated the expression of TYMS. e) Same as panel b) but for the HSP90 inhibitor tanespimycin.
