Extended Data Fig. 4: Analysis of ClinVar screen across readouts.
From: Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens
a, Scatterplot showing LFC of selected sgRNAs generating mutations in LCK, SOS1, and PTPRC. Timepoint shown is Day 28 post-electroporation in the ClinVar long-term expansion screen arm. b, Volcano plot showing enriched and depleted guides in the CFSE lo vs hi proliferation sort. For visualization purposes, one mutation for each labeled sgRNA is shown. One representative donor is shown. False discovery rate (FDR) cutoff <0.05. c, Volcano plot showing enriched and depleted guides in the CD25 hi vs lo proliferation sort. For visualization purposes, one mutation for each labeled sgRNA is shown. FDR cutoff <0.05. One representative donor is shown.
