Extended Data Fig. 4: Identified SNVs.
From: Saturation profiling of drug-resistant genetic variants using prime editing
Heatmap showing odds ratios and/or P-values of 2,610 (=870 × 3) SNVs generated by prime editing in exons 18-24 of EGFR ten days after the transduction of the Syn-exon18, Syn-exon19, …, Syn-exon24 libraries. SNVs with P-values greater than 0.05 by the two-sided Fisher’s exact test are indicated in red; in these cases, odds ratios are not shown. SNVs with odds ratios lower than 3 are shown with a white background. The numbers at the bottom of each heatmap represent the ___location in the EGFR coding sequence. At each position, the nucleotide in the reference sequence is shown. Edited reads were identified based on the the presence of both the intended edit and an additional synonymous edit.
