Extended Data Fig. 5: Evaluation of resistance profiles of EGFR protein variants.

a, Correlation between resistance scores following treatment with afatinib (left), osimertinib in the absence of T790M (middle), and osimertinib in the presence of T790M (right) in pairs of SNVs encoding the same protein variants. The classification of each protein variant is indicated by the dot color. Pearson correlation coefficients (r) are shown. The number of SNV pairs n = 218 (left), 218 (middle), and 210 (right). b, Correlation between resistance scores of protein variants following treatment with afatinib (left), osimertinib in the absence of T790M (middle), and osimertinib in the presence of T790M (right) in two biological replicates. The classification of each protein variant is indicated by the dot color. Pearson correlation coefficients are shown. The number of protein variants n = 1,726 (left), 1,726 (middle), and 1,671 (right). c, The number of sensitive and resistant protein variants functionally classified in the current study. The percentages of protein variants lacking previously published information about their effect on drug resistance, among all sensitive or resistant variants, are indicated on the blue bars.