Fig. 3: SCP-Nano reveals differences in LNP biodistribution based on different application routes.
From: Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning
a, Density heatmaps of the distribution of LNP-delivered mRNA applied using different routes (0.0005 mg kg−1 in each case). b, Raw projection images (left) and density heatmaps of selected organs. Arrows point to intra-organ delivery hotspots. c, Organ-level quantification of mRNA delivery events across key organs for different application routes using the SCP-Nano deep learning algorithm (n = 3 mice per group, mean ± s.d.). d, Quantification of mRNA delivery events in lymph nodes of intramuscularly injected mice. i.m., intramuscular; i.v., intravenous; LN, lymph node.
