Supplementary Figure 5: Dynamic DNA methylation at promoters and DNA methylation valleys during lineage specification.
From: Dynamic epigenomic landscapes during early lineage specification in mouse embryos

a Heatmap showing the promoter methylation (left) and expression (right) levels for genes that are differentially methylated between E6.5 VE and E6.5 Epi but are silenced in both lineages. b The GO analysis result for all genes located in DMVs identified in E6.5 Epi. c Barcharts showing the percentages of DMVs identified in early embryo (combining five lineages) that are marked by H3K27me3 (using data from a panel of somatic cells). d Barcharts showing the enrichment (logratio of observed/expected) of E5.5 Epi hypermethylated regions (vs. E6.5 Epi) in various classes of genomic elements. A set of random regions with equal lengths of individual hypermethylated regions were used as controls. e The boxplot showing the methylation levels in all CGIs and the non-CGI regions in DMVs in E5.5 and E6.5 embryos. f Barcharts showing the percentages of hypermethylated CGIs in E6.5 VE that fall into DMVs identified in early embryos (combining five lineages). The percentage of all CGIs that are located in DMVs (background) is also shown. g The barplot shows the expression of all Tet genes in early development