Supplementary Figure 9: Graphical description of the wtADCY3 C2 ___domain.
From: Loss-of-function mutations in ADCY3 cause monogenic severe obesity
a, Model-template sequence alignment. b, z score QMEAN, representing the model inside the non-redundant set of PDB structures regarding perfection. c, 3D structure of the C2 catalytic ___domain of wtADCY3. d, Superimposition of the C2 ___domain of Rattus norvegicus (rat) ADCY2 (in pink) on the C2 ___domain of human wtADCY3 (in blue). Here the Mg-ATP key interacting residues in both structures are also conserved.
