Supplementary Figure 2: Conservation of the ADCY3 mutated residues.
From: Loss-of-function mutations in ADCY3 cause monogenic severe obesity
Comparative sequence analysis showing conservation of the mutated ADCY3 regions at the protein level. Top, protein alignment for the homozygous mutations from consanguineous families. Bottom, protein alignment for the compound heterozygous mutation. Nucleotides in intronic regions are shaded gray.
