Fig. 5: Hierarchical clustering of heritability enrichments in the 220 cell-type-specific annotations. | Nature Genetics

Fig. 5: Hierarchical clustering of heritability enrichments in the 220 cell-type-specific annotations.

From: Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

Fig. 5

a, The significance of heritability enrichment among the 59 quantitative traits and 30 diseases, estimated via stratified LD score regression. Horizontal color bars correspond to the quantitative trait category for each column. Vertical color bars correspond to the cell-type groups for each row. b, A selected cluster of immune or hematopoietic cell types and various relevant traits and diseases. Another cluster highlighted in a is shown in Supplementary Fig. 9. FDR was calculated via the Benjamini–Hochberg method. Tmem, memory T cell; Treg, regulatory T cell; TH, helper T cell; TH17, IL-17-producing helper T cell; TH1, type 1 helper T cell; TH2, type 2 helper T cell; TH0, naive T cell; stim, stimulatory. Full trait and diseases abbreviations can be found in Tables 1 and 2.

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