Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

1. Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice and Rebecca S. Fine contributed equally to this work.

2. Guillaume Lettre, Kari E. North, Cecilia M. Lindgren, Joel N. Hirschhorn and Ruth J. F. Loos jointly directed this work.

Authors and Affiliations

1. Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada

   Valérie Turcot, Marie-Pierre Dubé, Ken S. Lo, John D. Rioux, Jean-Claude Tardif & Guillaume Lettre

2. Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA

   Yingchang Lu

3. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

   Yingchang Lu, Claudia Schurmann, Tamuno Alfred, Erwin P. Bottinger & Ruth J. F. Loos

4. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA

   Yingchang Lu, Claudia Schurmann & Ruth J. F. Loos

5. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA

   Heather M. Highland, Anne E. Justice, Mariaelisa Graff, Kristin L. Young & Angela L. Mazul

6. Human Genetics Center, University of Texas School of Public Health, University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA

   Heather M. Highland

7. Broad Institute of MIT and Harvard, Cambridge, MA, USA

   Rebecca S. Fine, Tõnu Esko, Alisa K. Manning, Sailaja Vedantam, Daniel I. Chasman, Patrick T. Ellinor, Jose C. Florez, Sekar Kathiresan, Steven A. Lubitz, Aniruddh P. Patel, Manuel A. Rivas & Joel N. Hirschhorn

8. Department of Genetics, Harvard Medical School, Boston, MA, USA

   Rebecca S. Fine, Sailaja Vedantam & Joel N. Hirschhorn

9. Division of Endocrinology and Center for Basic and Translational Obesity Research, Boston Children’s Hospital, Boston, MA, USA

   Rebecca S. Fine, Tõnu Esko, Sailaja Vedantam & Joel N. Hirschhorn

10. Center for Applied Genomics, Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Jonathan P. Bradfield, Struan F. A. Grant & Hakon Hakonarson

11. Quantinuum Research, LLC, San Diego, CA, USA

    Jonathan P. Bradfield

12. Estonian Genome Center, University of Tartu, Tartu, Estonia

    Tõnu Esko, Lili Milani & Markus Perola

13. Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA

    Ayush Giri & Todd L. Edwards

14. Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, CA, USA

    Xiuqing Guo, Yii-Der I. Chen, Yucheng Jia, Eric Kim, Kent D. Taylor, Jie Yao & Jerome I. Rotter

15. Wellcome Trust Sanger Institute, Hinxton, UK

    Audrey E. Hendricks, Inês Barroso, John Danesh, Gaëlle Marenne, Lorraine Southam & Eleftheria Zeggini

16. Department of Mathematical and Statistical Sciences, University of Colorado, Denver, CO, USA

    Audrey E. Hendricks

17. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK

    Tugce Karaderi, Anubha Mahajan, Wei Gan, Hidetoshi Kitajima, Mark I. McCarthy, Andrew P. Morris, Neil R. Robertson, Lorraine Southam, Krina T Zondervan & Cecilia M. Lindgren

18. Department of Biological Sciences, Faculty of Arts and Sciences, Eastern Mediterranean University, Famagusta, Cyprus

    Tugce Karaderi

19. Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany

    Adelheid Lempradl & John A. Pospisilik

20. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA

    Adam E. Locke, Gonçalo Abecasis, Michael Boehnke, Shuang Feng, Anne U. Jackson, Xueling Sim & Heather M. Stringham

21. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

    Adam E. Locke

22. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Eirini Marouli, Sameer E. Alharthi, Mark J. Caulfield, Stavroula Kanoni, Patricia B. Munroe, Kathleen E. Stirrups, Helen R. Warren & Panos Deloukas

23. Department of Vascular Medicine, AMC, Amsterdam, The Netherlands

    Suthesh Sivapalaratnam & G. Kees Hovingh

24. Massachusetts General Hospital, Boston, MA, USA

    Suthesh Sivapalaratnam, Alisa K. Manning, Patrick T. Ellinor, Jose C. Florez, Paul L. Huang, Sekar Kathiresan, Steven A. Lubitz & Aniruddh P. Patel

25. Department of Haematology, University of Cambridge, Cambridge, UK

    Suthesh Sivapalaratnam & Kathleen E. Stirrups

26. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

    Mary F. Feitosa & Ingrid B. Borecki

27. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK

    Nicholas G. D. Masca, Christopher P. Nelson & Nilesh J. Samani

28. NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK

    Nicholas G. D. Masca, Christopher P. Nelson & Nilesh J. Samani

29. Department of Medicine, Harvard Medical School, Boston, MA, USA

    Alisa K. Manning & Jose C. Florez

30. Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA

    Alisa K. Manning, Patrick T. Ellinor, Jose C. Florez & Steven A. Lubitz

31. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands

    Carolina Medina-Gomez, Oscar H. Franco, M. Arfan Ikram, André G. Uitterlinden, Cornelia M. Duijn & Fernando Rivadeneira

32. Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

    Carolina Medina-Gomez, Linda Broer, André G. Uitterlinden & Fernando Rivadeneira

33. Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Poorva Mudgal, Maggie C. Y. Ng, Donald W. Bowden & Amanda J. Cox

34. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Maggie C. Y. Ng, Donald W. Bowden & Amanda J. Cox

35. Department of Epidemiology, University of Washington, Seattle, WA, USA

    Alex P. Reiner

36. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Alex P. Reiner, Mengmeng Du, Jeff Haessler & Charles Kooperberg

37. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK

    Sara M. Willems, Claudia Langenberg, Jian’an Luan, John R. B. Perry, Robert A. Scott, Nicholas J. Wareham & Jing Hua Zhao

38. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

    Thomas W. Winkler, Mathias Gorski & Iris M. Heid

39. Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands

    Katja K. Aben

40. Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

    Katja K. Aben, Tessel E. Galesloot, Lambertus A. Kiemeney & Sita H. Vermeulen

41. School of Kinesiology and Health Science, Faculty of Health, York University, Toronto, Ontario, Canada

    Dewan S. Alam

42. Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia

    Sameer E. Alharthi & Panos Deloukas

43. Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, USA

    Matthew Allison

44. INSERM U1167, Lille, France

    Philippe Amouyel

45. Institut Pasteur de Lille, U1167, Lille, France

    Philippe Amouyel

46. Université de Lille, U1167, RID-AGE, Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France

    Philippe Amouyel

47. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

    Folkert W. Asselbergs & Jessica van Setten

48. Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands

    Folkert W. Asselbergs

49. Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK

    Folkert W. Asselbergs

50. Zilber School of Public Health, University of Wisconsin–Milwaukee, Milwaukee, WI, USA

    Paul L. Auer

51. INSERM U1018, Centre de Recherche en Épidémiologie et Santé des Populations (CESP), Villejuif, France

    Beverley Balkau

52. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

    Lia E. Bang

53. Metabolic Research Laboratories, University of Cambridge, Cambridge, UK

    Inês Barroso, I. Sadaf Farooqi & Vanisha Mistry

54. NIHR Cambridge Biomedical Research Centre, Wellcome Trust–MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK

    Inês Barroso, I. Sadaf Farooqi & Vanisha Mistry

55. Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA

    Lisa Bastarache & Josh C. Denny

56. Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark

    Marianne Benn, Pia R. Kamstrup, Sune F. Nielsen, Børge G. Nordestgaard & Anette Varbo

57. Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Marianne Benn, Ruth Frikke-Schmidt, Torben Jørgensen, Sune F. Nielsen, Børge G. Nordestgaard, Anne Tybjaerg-Hansen & Anette Varbo

58. Department of Computational Biology, University of Lausanne, Lausanne, Switzerland

    Sven Bergmann & David Lamparter

59. Swiss Institute of Bioinformatics, Lausanne, Switzerland

    Sven Bergmann, Zoltán Kutalik & David Lamparter

60. Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA

    Lawrence F. Bielak, Sharon L. R. Kardia, Patricia A. Peyser, Erin B. Ware & Wei Zhao

61. IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany

    Matthias Blüher, Peter Kovacs & Michael Stumvoll

62. Department of Medicine, University of Leipzig, Leipzig, Germany

    Matthias Blüher & Michael Stumvoll

63. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany

    Heiner Boeing

64. School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA

    Eric Boerwinkle & Megan L. Grove

65. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA

    Eric Boerwinkle

66. Department of Nephrology, University Hospital Regensburg, Regensburg, Germany

    Carsten A. Böger, Mathias Gorski & Myriam Rheinberger

67. Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Jette Bork-Jensen, Anette P. Gjesing, Niels Grarup, Torben Hansen, Christian T. Have, Oluf Pedersen, Tune H. Pers & Henrik Vestergaard

68. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

    Michiel L. Bots & Paul I. W. Bakker

69. Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA

    Donald W. Bowden & Nicholette D. Palmer

70. Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark

    Ivan Brandslund

71. Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark

    Ivan Brandslund

72. MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

    Gerome Breen

73. NIHR Biomedical Research Centre for Mental Health, South London and Maudsley Hospital, London, UK

    Gerome Breen

74. Marshfield Clinic Research Institute, Marshfield, WI, USA

    Murray H. Brilliant, Peggy L. Peissig & Thomas N. Person

75. Department of Medical Sciences, University of Trieste, Trieste, Italy

    Marco Brumat, Paolo Gasparini & Dragana Vuckovic

76. Department of Medicine, University of Washington, Seattle, WA, USA

    Amber A. Burt, Gail P. Jarvik & Eric B. Larson

77. MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

    Adam S. Butterworth, Rajiv Chowdhury, John Danesh, Emanuele Angelantonio, Joanna M. M. Howson, Praveen Surendran & Robin Young

78. NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

    Adam S. Butterworth, John Danesh, Emanuele Angelantonio, Carmel Moore & David J. Roberts

79. Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA

    Peter T. Campbell

80. Institute for Maternal and Child Health, IRCCS ‘Burlo Garofolo’, Trieste, Italy

    Stefania Cappellani, Eulalia Catamo, Angela D’Eustacchio, Paolo Gasparini, Antonietta Robino & Dragana Vuckovic

81. Weis Center for Research, Geisinger Health System, Danville, PA, USA

    David J. Carey, Helena Kuivaniemi & Gerard Tromp

82. NIHR Barts Cardiovascular Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK

    Mark J. Caulfield, Patricia B. Munroe & Helen R. Warren

83. Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex, UK

    John C. Chambers, Jaspal S. Kooner & Weihua Zhang

84. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

    John C. Chambers, Evangelos Evangelou, Marcelo P. Segura-Lepe & Weihua Zhang

85. Imperial College Healthcare NHS Trust, London, UK

    John C. Chambers & Jaspal S. Kooner

86. Division of Genetics, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Daniel I. Chasman

87. Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Daniel I. Chasman & Paul M. Ridker

88. Harvard Medical School, Boston, MA, USA

    Daniel I. Chasman, Sekar Kathiresan, Aniruddh P. Patel & Paul M. Ridker

89. Medical Department, Lillebaelt Hospital, Vejle, Denmark

    Cramer Christensen

90. NHLBI Framingham Heart Study, Framingham, MA, USA

    Audrey Y. Chu & Nancy L. Heard-Costa

91. Genetics and Pharmacogenomics, Merck, Sharp & Dohme, Boston, MA, USA

    Audrey Y. Chu & Dermot F. Reilly

92. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

    Massimiliano Cocca

93. Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, MD, USA

    Francis S. Collins, Narisu Narisu & Amy J. Swift

94. Department of Biostatistics, University of Liverpool, Liverpool, UK

    James P. Cook, Gail Davies, Ian J. Deary & Andrew P. Morris

95. Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK

    Janie Corley, Gail Davies, Ian J. Deary & John M. Starr

96. Department of Psychology, University of Edinburgh, Edinburgh, UK

    Janie Corley & Alison Pattie

97. Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands

    Jordi Corominas Galbany

98. Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands

    Jordi Corominas Galbany & Anneke I. Hollander

99. Menzies Health Institute Queensland, Griffith University, Southport, Queensland, Australia

    Amanda J. Cox

100. Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, USA

     David S. Crosslin

101. Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia

     Gabriel Cuellar-Partida

102. QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia

     Gabriel Cuellar-Partida, Sarah E. Medland, Grant W. Montgomery, Dale R. Nyholt & Yadav Sapkota

103. British Heart Foundation Cambridge Centre of Excellence, Department of Medicine, University of Cambridge, Cambridge, UK

     John Danesh

104. Department of Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands

     Paul I. W. Bakker

105. Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands

     Mark C. H. Groot

106. Utrecht Institute for Pharmaceutical Sciences, Division Pharmacoepidemiology and Clinical Pharmacology, Utrecht University, Utrecht, The Netherlands

     Mark C. H. Groot

107. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands

     Renée Mutsert, Ruifang Li-Gao & Dennis O. Mook-Kanamori

108. Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece

     George Dedoussis & Aliki-Eleni Farmaki

109. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA

     Ellen W. Demerath & Pamela J. Schreiner

110. Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands

     Martin Heijer

111. Laboratory of Experimental Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

     Hester M. Ruijter, Gerard Pasterkamp & Sander W. Laan

112. Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

     Joe G. Dennis, Douglas F. Easton & Deborah J. Thompson

113. Institute of Cardiovascular Science, University College London, London, UK

     Fotios Drenos

114. MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK

     Fotios Drenos & Katherine E. Tansey

115. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

     Mengmeng Du

116. Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada

     Marie-Pierre Dubé, John D. Rioux & Guillaume Lettre

117. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK

     Alison M. Dunning, Douglas F. Easton, Ailith Pirie & Jonathan P. Tyrer

118. Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany

     David Ellinghaus & Andre Franke

119. Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK

     Paul Elliott

120. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

     Evangelos Evangelou

121. Department of Health Sciences, University of Leicester, Leicester, UK

     Aliki-Eleni Farmaki

122. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA

     Jessica D. Faul & Erin B. Ware

123. Department of Ophthalmology, University of Cologne, Cologne, Germany

     Sascha Fauser

124. CNR Institute of Clinical Physiology, Pisa, Italy

     Ele Ferrannini

125. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

     Ele Ferrannini

126. Toulouse University School of Medicine, Toulouse, France

     Jean Ferrieres

127. University of Glasgow, Glasgow, UK

     Ian Ford, Chris J. Packard, Sandosh Padmanabhan, Naveed Sattar & Robin Young

128. Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA

     Myriam Fornage & Li-An Lin

129. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmo, Sweden

     Paul W. Franks, Frida Renström & Tibor V. Varga

130. Department of Nutrition, Harvard School of Public Health, Boston, MA, USA

     Paul W. Franks

131. Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå, Sweden

     Paul W. Franks

132. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

     Nele Friedrich

133. Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

     Ruth Frikke-Schmidt & Anne Tybjaerg-Hansen

134. Research Unit, AREA Science Park, Trieste, Italy

     Ilaria Gandin

135. Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK

     Jane Gibson

136. Geriatrics, Department of Public Health, Uppsala University, Uppsala, Sweden

     Vilmantas Giedraitis

137. Carolina Population Center, University of North Carolina, Chapel Hill, NC, USA

     Penny Gordon-Larsen & Kathleen Mullan Harris

138. Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA

     Penny Gordon-Larsen

139. Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

     Hans-Jörgen Grabe

140. German Center for Neurodegenerative Diseases (DZNE), Rostock/Greifswald, Greifswald, Germany

     Hans-Jörgen Grabe

141. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

     Struan F. A. Grant & Hakon Hakonarson

142. Division of Endocrinology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

     Struan F. A. Grant

143. Vision Sciences, Clinical Neurosciences Research Group, Faculty of Medicine, University of Southampton, Southampton, UK

     Helen L. Griffiths & Andrew J. Lotery

144. Faculty of Medicine, University of Iceland, Reykjavik, Iceland

     Vilmundur Gudnason, Albert V. Smith, Kari Stefansson & Unnur Thorsteinsdottir

145. Icelandic Heart Association, Kopavogur, Iceland

     Vilmundur Gudnason & Albert V. Smith

146. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden

     Stefan Gustafsson & Erik Ingelsson

147. Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, VU University Amsterdam, Amsterdam, The Netherlands

     Anke R. Hammerschlag & Tinca J. Polderman

148. Department of Sociology, University of North Carolina, Chapel Hill, NC, USA

     Kathleen Mullan Harris

149. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA

     Tamara B. Harris

150. University of Exeter Medical School, University of Exeter, Exeter, UK

     Andrew T. Hattersley

151. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK

     Caroline Hayward, Jennifer E. Huffman & Veronique Vitart

152. Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, NC, USA

     Liang He & Liang Sun

153. Department of Public Health, University of Helsinki, Helsinki, Finland

     Liang He, Jaakko Kaprio, Tellervo Korhonen, Anu Loukola & Liang Sun

154. Department of Neurology, Boston University School of Medicine, Boston, MA, USA

     Nancy L. Heard-Costa

155. Department of Psychiatry, Washington University, St. Louis, MO, USA

     Andrew C. Heath

156. Institute of Genetic Epidemiology, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany

     Iris M. Heid, Martina Müller-Nurasyid & Konstantin Strauch

157. Department of Pediatrics, Haukeland University Hospital, Bergen, Norway

     Øyvind Helgeland & Pål R. Njølstad

158. KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway

     Øyvind Helgeland, Stefan Johansson & Pål R. Njølstad

159. Department of Cardiology, Heart Center, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

     Jussi Hernesniemi & Kjell Nikus

160. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

     Jussi Hernesniemi, Terho Lehtimäki & Leo-Pekka Lyytikäinen

161. Department of Clinical Chemistry, Finnish Cardiovascular Research Center–Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

     Jussi Hernesniemi, Terho Lehtimäki & Leo-Pekka Lyytikäinen

162. Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, Australia

     Alex W. Hewitt

163. Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, Australia

     Alex W. Hewitt

164. Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia

     Alex W. Hewitt

165. KG Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway

     Oddgeir L. Holmen

166. Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, China

     Yao Hu, Huaixing Li, Xu Lin, Feijie Wang, Yiqin Wang & Pang Yao

167. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands

     M. Arfan Ikram

168. Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands

     M. Arfan Ikram

169. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA

     Erik Ingelsson & Jin Li

170. Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

     Jan-Håkan Jansson & Olov Rolandsson

171. Research Unit Skellefteå, Skellefteå, Sweden

     Jan-Håkan Jansson

172. Department of Genome Sciences, University of Washington, Seattle, WA, USA

     Gail P. Jarvik

173. Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, Denmark

     Gorm B. Jensen

174. Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

     Stefan Johansson

175. National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark

     Marit E. Jørgensen

176. Steno Diabetes Center Copenhagen, Gentofte, Denmark

     Marit E. Jørgensen & Henrik Vestergaard

177. Faculty of Medicine, Aalborg University, Aalborg, Denmark

     Torben Jørgensen

178. Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, Denmark

     Torben Jørgensen, Allan Linneberg & Betina H. Thuesen

179. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands

     J. Wouter Jukema & Stella Trompet

180. Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands

     J. Wouter Jukema

181. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA

     Bratati Kahali, Elizabeth K. Speliotes, Cristen J. Willer & Wei Zhou

182. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

     Bratati Kahali, Elizabeth K. Speliotes, Cristen J. Willer & Wei Zhou

183. Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA

     Bratati Kahali & Elizabeth K. Speliotes

184. Centre for Brain Research, Indian Institute of Science, Bangalore, India

     Bratati Kahali

185. Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands

     René S. Kahn & Roel A. Ophoff

186. Department of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland

     Mika Kähönen

187. Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland

     Mika Kähönen

188. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland

     Jaakko Kaprio, Anu Loukola & Markus Perola

189. National Institute for Health and Welfare, Helsinki, Finland

     Jaakko Kaprio, Tellervo Korhonen, Kari Kuulasmaa, Jaana Lindström, Satu Männistö, Markus Perola, Veikko Salomaa & Jaakko Tuomilehto

190. Echinos Medical Centre, Echinos, Greece

     Maria Karaleftheri

191. Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

     Fredrik Karpe, Mark I. McCarthy, Matt Neville, Katharine R. Owen & Neil R. Robertson

192. Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK

     Fredrik Karpe, Mark I. McCarthy, Matt Neville & Katharine R. Owen

193. UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast, UK

     Frank Kee

194. Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

     Pirjo Komulainen, Timo A. Lakka & Rainer Rauramaa

195. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland

     Pirjo Komulainen, Timo A. Lakka & Rainer Rauramaa

196. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland

     Pirjo Komulainen & Timo A. Lakka

197. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital Campus, London, UK

     Jaspal S. Kooner

198. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK

     Jaspal S. Kooner

199. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

     Tellervo Korhonen

200. Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

     Helena Kuivaniemi

201. Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

     Helena Kuivaniemi & Gerard Tromp

202. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland

     Zoltán Kutalik

203. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

     Johanna Kuusisto & Markku Laakso

204. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA

     Ethan M. Lange, Leslie A. Lange, Karen L. Mohlke & Ying Wu

205. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA

     Eric B. Larson

206. Department of Health Services, University of Washington, Seattle, WA, USA

     Eric B. Larson

207. Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines

     Nanette R. Lee

208. USC–Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines

     Nanette R. Lee

209. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

     Cora E. Lewis

210. Department of Medicine, Boston University School of Medicine, Boston, MA, USA

     Honghuang Lin

211. Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan

     Keng-Hung Lin

212. Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden

     Lars Lind

213. Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark

     Allan Linneberg

214. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

     Allan Linneberg

215. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

     Ching-Ti Liu, Gina M. Peloso & Shuai Wang

216. Department of Public Health Sciences, Institute for Personalized Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA

     Dajiang J. Liu

217. Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA

     Yongmei Liu & Lynne E. Wagenknecht

218. Division of Health Sciences, Warwick Medical School, Warwick University, Coventry, UK

     Artitaya Lophatananon

219. Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA

     Roberta McKean-Cowdin

220. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany

     Karina Meidtner & Matthias B. Schulze

221. German Center for Diabetes Research, Neuherberg, Germany

     Karina Meidtner, Annette Peters & Matthias B. Schulze

222. Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, Australia

     Paul Mitchell

223. Department of Medicine, Kuopio University Hospital, Kuopio, Finland

     Leena Moilanen

224. Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, France

     Marie Moitry

225. Department of Public Health, University Hospital of Strasbourg, Strasbourg, France

     Marie Moitry

226. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia

     Grant W. Montgomery

227. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands

     Dennis O. Mook-Kanamori

228. INTERVAL Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

     Carmel Moore

229. School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia

     Trevor A. Mori

230. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK

     Andrew D. Morris, Ozren Polasek & Igor Rudan

231. Department of Medicine I, University Hospital Großhadern, Ludwig-Maximilians-Universitat, Munich, Germany

     Martina Müller-Nurasyid

232. German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany

     Martina Müller-Nurasyid & Annette Peters

233. Laboratory of Neurogenetics, National Institute on Aging, US National Institutes of Health, Bethesda, MD, USA

     Mike A. Nalls

234. Data Tecnica International, Glen Echo, MD, USA

     Mike A. Nalls

235. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia

     Dale R. Nyholt

236. Program for Personalized and Genomic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA

     Jeffrey R. O’Connel, James A. Perry & Laura M. Yerges-Armstrong

237. Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

     Michelle L. O’Donoghue, Paul M. Ridker & Hayato Tada

238. Center for Neurobehavioral Genetics, University of California, Los Angeles, Los Angeles, CA, USA

     Loes M. Olde Loohuis & Roel A. Ophoff

239. Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee, UK

     Colin N. A. Palmer

240. Laboratory of Clinical Chemistry and Hematology, Division of Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, The Netherlands

     Gerard Pasterkamp

241. School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia

     Craig E. Pennell & Carol A. Wang

242. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland

     Markus Perola

243. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark

     Tune H. Pers

244. Institute of Epidemiology II, Helmholtz Zentrum München–German Research Center for Environmental Health, Neuherberg, Germany

     Annette Peters

245. Department of Clinical Immunology and Biochemistry, Lillebaelt Hospital, Vejle, Denmark

     Eva R. B. Petersen

246. School of Medicine, University of Split, Split, Croatia

     Ozren Polasek

247. Central Hospital of Southern Ostrobothnia, Seinäjoki, Finland

     Hannu Puolijoki

248. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

     Olli T. Raitakari

249. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

     Olli T. Raitakari

250. Centre for Non-Communicable Diseases, Karachi, Pakistan

     Asif Rasheed & Danish Saleheen

251. Department of Biobank Research, Umeå University, Umeå, Sweden

     Frida Renström

252. Wellcome Trust Centre for Human Genetics, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK

     Manuel A. Rivas

253. NHS Blood and Transplant–Oxford Centre, Oxford, UK

     David J. Roberts

254. BRC Haematology Theme and Radcliffe Department of Medicine, University of Oxford, Oxford, UK

     David J. Roberts

255. Department of Public Health and Clinical Medicine, Unit of Family Medicine, Umeå University, Umeå, Sweden

     Olov Rolandsson

256. Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK

     Katherine S. Ruth, Andrew R. Wood, Hanieh Yaghootkar & Timothy M. Frayling

257. Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

     Danish Saleheen & Wei Zhao

258. Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

     Robert E. Schoen

259. Duke Molecular Physiology Institute, Duke University, Durham, NC, USA

     Svati H. Shah

260. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

     Wayne H.-H. Sheu

261. School of Medicine, National Defense Medical Center, Taipei, Taiwan

     Wayne H.-H. Sheu

262. School of Medicine, National Yang-Ming University, Taipei, Taiwan

     Wayne H.-H. Sheu

263. Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore

     Xueling Sim

264. Genetics, Target Sciences, GlaxoSmithKline, Research Triangle Park, NC, USA

     Andrew J. Slater

265. OmicSoft at Qiagen Company, Cary, NC, USA

     Andrew J. Slater

266. Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK

     Kerrin S. Small & Timothy D. Spector

267. Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK

     John M. Starr

268. deCODE Genetics/Amgen, Inc., Reykjavik, Iceland

     Kari Stefansson, Valgerdur Steinthorsdottir, Gudmar Thorleifsson & Unnur Thorsteinsdottir

269. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany

     Konstantin Strauch

270. Kanazawa University, Kanazawa, Japan

     Hayato Tada

271. College of Biomedical and Life Sciences, Cardiff University, Cardiff, UK

     Katherine E. Tansey

272. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

     Alexander Teumer

273. Center for Pediatric Research, Department for Women’s and Child Health, University of Leipzig, Leipzig, Germany

     Anke Tönjes

274. Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

     Stella Trompet

275. Anogia Medical Centre, Anogia, Greece

     Emmanouil Tsafantakis

276. Centre for Vascular Prevention, Danube University Krems, Krems, Austria

     Jaakko Tuomilehto

277. Dasman Diabetes Institute, Dasman, Kuwait

     Jaakko Tuomilehto

278. Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia

     Jaakko Tuomilehto

279. Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada

     Rudolf Uher

280. Department of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

     Matti Uusitupa

281. Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands

     Nienke Leeuwen

282. Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands

     Nienke Leeuwen

283. Primary Health Care Unit, Central Hospital of Central Finland, Jyväskylä, Finland

     Mauno Vanhala

284. Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland

     Mauno Vanhala

285. USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA

     Rohit Varma

286. Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, TN, USA

     Digna R. Velez Edwards

287. Research Center on Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy

     Giovanni Veronesi

288. Cardiometabolic Disease, Merck, Sharp & Dohme, Kenilworth, NJ, USA

     Thomas F. Vogt

289. German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany

     Uwe Völker

290. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

     Uwe Völker

291. Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle, UK

     Mark Walker

292. Department of Medical Sciences, Cardiology, Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden

     Lars Wallentin

293. Genetics, Target Sciences, GlaxoSmithKline, King of Prussia, PA, USA

     Dawn M. Waterworth

294. Departments of Epidemiology and Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health and School of Medicine, Indiana University, Indianapolis, IN, USA

     Jennifer Wessel

295. Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand

     Harvey D. White

296. Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA

     Cristen J. Willer

297. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA

     James G. Wilson

298. Danish Diabetes Academy, Odense, Denmark

     Daniel R. Witte

299. Department of Public Health, Aarhus University, Aarhus, Denmark

     Daniel R. Witte

300. GlaxoSmithKline, King of Prussia, PA, USA

     Laura M. Yerges-Armstrong

301. Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX, USA

     Xiaowei Zhan

302. Endometriosis CaRe Centre, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, UK

     Krina T Zondervan

303. Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, NC, USA

     Kari E. North

304. Li Ka Shing Centre for Health Information and Discovery, Big Data Institute, University of Oxford, Oxford, UK

     Cecilia M. Lindgren

305. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

     Joel N. Hirschhorn

306. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

     Ruth J. F. Loos

Consortia

Corresponding authors

Correspondence to Joel N. Hirschhorn or Ruth J. F. Loos.

The original article can be found online at https://doi.org/10.1038/s41588-017-0011-x.

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