Supplementary Figure 8: Subcellular layout of the top network from IPA analysis of significant DBP genes in aorta.

Genes significant (P < 2.5 × 10^–7) in S-PrediXcan analysis of DBP GWAS loci in aorta were provided as input for IPA. Biological networks ranked by the number of overlapping loci were generated, and the top network is presented here. Eleven of 27 molecules are represented by genes significant in S-PrediXcan analyses, as indicated by node coloring. Arrows indicate the direction of the relationship, while solid lines indicate direct interaction (for example, phosphorylation) and broken lines indicate indirect relationships (for example, activation). Interactions without direction (for example, protein–protein) do not have an arrow. Nodes outlined in purple indicate overlay of hematopoiesis (enrichment P = 6.57 × 10^–7) and hematological system and development (enrichment P = 6.57 × 10^–7) pathways. Right-tailed Fisher’s exact test was performed to obtain enrichment P values without correction for multiple testing.