Supplementary Figure 5: Comparison of effect sizes for significant PheWAS results identified with SBP, DBP, and pulse pressure across whites, blacks, and Hispanics.

Genetic risk scores (GRS) weighted for SBP, DBP and pulse pressure were regressed onto the clinical phenome in whites (maximum n = 188,008 biologically independent samples), blacks (maximum n = 52,530 biologically independent samples) and Hispanics (maximum n = 16,735 biologically independent samples) separately. Effect estimates for phenotypes that were significant in whites, blacks or Hispanics were compared across three ethnicities. Comparison of effect estimates are presented in the following order: blacks and whites (row 1), Hispanics and whites (row 2) and Hispanics and blacks (row 3) for SBP, DBP and pulse pressure (left to right). R² denotes correlation between effect estimates calculated from a linear regression model. The blue line represents the regression line, and the shaded area represents the 95% confidence interval.