Supplementary Figure 3: Global changes in chromatin organization during cardiomyocyte differentiation. | Nature Genetics

Supplementary Figure 3: Global changes in chromatin organization during cardiomyocyte differentiation.

From: Transcriptionally active HERV-H retrotransposons demarcate topologically associating domains in human pluripotent stem cells

Supplementary Figure 3

(a) Frequency distribution of Hi-C contacts over genomic distances (log2) at different stages of cardiomyocyte differentiation (colored lines). (b) Barplot showing the percentages of compartment switches for each stage transition. (c) A histogram showing the distribution of the Pearson correlation coefficients (PCC) between gene expression levels and PC1 (indicating compartment A or B) value derived from the Hi-C contact matrix. (d) Snapshots of genome browser view of SOX2, HAND2 and RYR2 loci, showing PC1 values (Blue/red), RNA-seq (Black) and H3K27ac (Blue) signals.

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