Extended Data Fig. 7: Peptides encoded by dACE2-Ex1c are detected by protein sequencing in tumors. | Nature Genetics

Extended Data Fig. 7: Peptides encoded by dACE2-Ex1c are detected by protein sequencing in tumors.

From: Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

Extended Data Fig. 7

a, Results of peptide query in PepQuery2 proteomics database of mass-spec data in 174 ovarian, 95 colon, and 105 breast tumors in TCGA7. Three peptides – MREAGWDK, EAGWDKGGR, and GGRILMCTK uniquely correspond to the 10 aa encoded by dACE2-Ex1c. The latter peptide results from the splicing of dACE2-Ex1c with its downstream exon. The total number of identified peptides, the number of samples with specific peptides, and corresponding parameters for a peptide-spectrum match (PSM) are shown in table format. b, Representative spectra of two peptides matching with the protein encoded by dACE2-Ex1c. M/z refers to the mass by charge ratio. The b-series and y-series ions showed the correct mapping of residues in the query aa sequence.

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