Fig. 4: dACE2 is induced in virally infected human respiratory cells. | Nature Genetics

Fig. 4: dACE2 is induced in virally infected human respiratory cells.

From: Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

Fig. 4

a–e, Expression patterns of ACE2, represented by Ex1a and Ex1b, and dACE2, represented by Ex1c, in uninfected and rhinovirus (RV)-infected human nasal epithelial cells (a–c) and in uninfected and influenza H3N2–infected cells from human lung explants (d,e). a, RNA-seq Sashimi plots. b,d, First-exon-specific expression levels of ACE2 and dACE2 are presented by box-and-whisker plots as: mean (+), median (center line), box (25th to 75th interquartile range), whiskers (5th–90th percentile range) and outliers (individual data points). FC, fold change compared to mock. The P values are for non-parametric, two-sided Wilcoxon matched-pairs signed rank tests. c,e, Pearson correlation coefficients with P values for two-sided tests for exon-specific expression levels of ACE2 and dACE2 with select ISGs and IFNs in the full datasets.

Back to article page