Extended Data Fig. 6: H3K27ac signal is significantly different in 203 lead vs. 203 random SNPs for relevant facial tissues.
From: Insights into the genetic architecture of the human face
For all cell types and tissues, each represented by a point above, the median difference between H3K27ac RPM signal between the 203 lead SNPs vs. 203 random SNPs was tested for significance using a two-sided Wilcoxon rank-sum test. The thin dashed line represents the 5% false discovery rate P value of 0.0094, using the Benjamini–Hochberg method. Relative to the random, MAF-matched SNPs, the lead SNPs are significantly enriched for H3K27ac signal in many cell types, with the highest magnitude differences being from CNCCs (blue) and embryonic craniofacial tissues (orange). Test statistics used to create this plot are available in Supplementary Table 4.
