Extended Data Fig. 7: Correlation of H3K27ac activity among SEM models.
From: Insights into the genetic architecture of the human face
a, For all segments (aka ‘masks’), we compared the H3K27ac activity for significant SNPs from the refined SEM model for variation in that facial segment. Plotted is the Spearman’s rho correlation between pairs of SNPs significant in the same SEM model (‘Within Mask’); pairs of SNPs where one is from the SEM model and the other is not (‘Within To Out’), and where both SNPs in the pair are from a different SEM model (‘Out To Out’). Segments where the distribution of correlation across all cell types was significantly different (Benjamini–Hochberg adjusted P < 0.05) based on a two-sided Kruskal–Wallis test are indicated in black. b, For all cell types, the median correlation across all segments is plotted for each of the three SNP groupings. Significance between the means was determined using a two-sided Kruskal–Wallis test. Boxplots plot the first and third quartiles, with a dark black line representing the median. Whiskers extend to the largest and smallest values no further than 1.5 × the inter-quartile range from the first and third quartiles, respectively.
