Extended Data Fig. 3: Intra-TAD activity cross-comparison of T-ALL sub-types.
From: Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia
a) Comparisons of intra-TAD activity between T cells, T-ALL and ETP-ALL samples. b) Overlap of differentially active TADs between the two comparisons of T cells vs T-ALL and T cells vs ETP-ALL, visualized as venn diagram. Red and blue colors correspond to differences as highlighted in a). c, d) Integration of RNA-seq (FPKM > 1) within TADs with decreased / increased intra-TAD activity for ETP-ALL vs T cells (c) and ETP-ALL vs T-ALL (d). For each such gene, the log2 (fold-change) in expression between ETP-ALL and T cells (c) / T-ALL and ETP-ALL (d) taken from RNA-seq is shown. Significant differences are calculated by an unpaired one-sided t test comparing genes from TADs with decreased / increased intra-TAD activity with genes from stable TADs, following the hypothesis of a positive correlation between expression and intra-TAD activity changes. Boxplot information can be found as additional Source Data.
