Extended Data Fig. 9: Selective and enriched dependencies in pediatric and adult solid tumor lines.

a, The frequency of dependency on the neuroblastoma core regulatory transcription factors (ISL1, HAND2, GATA3, PHOX2A, PHOX2B) and rhabdomyosarcoma regulatory transcription factors (MYOD1) are depicted in pediatric and adult solid tumor types with at least 3 cell lines screened per type in polar bar graphs. The tumor types are colored as in the legend. The neuroblastoma transcription factor dependencies were seen uniquely in neuroblastoma and MYOD1 dependency was seen in rhabdomyosarcoma. b, Feature importance for the predictive models of HDAC2 dependency using data from all solid and brain tumor cell lines (left) or pediatric solid and brain cancer cell lines only (right). The y-axis shows the feature importance as calculated by the predictive model with features listed on the x-axis. c, Feature importance for the predictive models of HDAC2 dependency using data from all solid and brain tumor cell lines (left) or pediatric solid and brain cancer cell lines only (right). The y-axis shows the feature importance as calculated by the predictive model with features listed on the x-axis.