Fig. 3: Orientation-biased CTCF and Rad21 enrichment at TAD borders of higher DI values.
From: Three-dimensional folding dynamics of the Xenopus tropicalis genome
a, DI for three clusters of TADs identified in embryos at s13: 555, 3,191 and 414 TADs in clusters 1, 2 and 3, respectively. b, CTCF enrichment is biased to borders with higher DI values. c, Rad21 enrichment is biased to borders with higher DI values and drops toward the border on the other side of the TAD. a–c, Data are presented as the mean ± s.e.m. d, DI for TADs of cluster 1, five subclusters of clusters 2 and cluster 3. According to the ranking of DI strength, TADs in cluster 2 were divided into five subclusters. Data are presented as box plots within violin plots. The minima, maxima, center and bounds of each box plot refers to quartile 1–1.5 interquartile range, quartile 3 + 1.5 interquartile range, median, first and third quartiles of the data. e, Examples of TADs for the three different clusters. f, Aggregated heatmaps for three clusters of TADs. g, Histone modifications and p300 enrichment patterns across the borders of three clusters of TADs. Data are presented as the mean ± s.e.m.
