Extended Data Fig. 5: Effects of SPTBN1 variants on dendrites.
From: Pathogenic SPTBN1 variants cause an autosomal dominant neurodevelopmental syndrome
a, Images of DIV18 βII-SpWT, βII-SpHet, βII-SpKO, and GFP-βIISp rescued βII-SpKO neurons stained with an anti-GFP antibody. Scale bar, 30 μm. b,c, Quantification of length of primary dendrites (b) and of total number of primary and secondary dendrites (c) of βII-SpWT, βII-SpHet, βII-SpKO, and rescued βII-SpKO DIV18 neurons (n = 6-16 neurons/genotype) compiled from three independent experiments. Data represent mean ± SEM. One-way ANOVA with Dunnett’s post hoc analysis test for multiple comparisons, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. See statistics summary in Source Data Extended Data Fig. 5.
