Extended Data Fig. 1: m6A landscape across tissues.
From: Genetic drivers of m6A methylation in human brain, lung, heart and muscle
a. Positional enrichment for aggregated meRIP-seq signal surrounding the known m6A motif (GGACH) vs. three control sequences (colors). b. m6A peak positional density (y-axis) along the gene structure (x-axis) in brain, lung, heart and muscle. c. Cumulative distribution (y-axis) of GGACH motif enrichment (-log10q-value, x-axis) across samples (teal) vs. shuffled controls (salmon). d. Peak Count per sample. e. Peaks shared by fewer individuals (left) are more likely previously-undetected (red). f. Similar to b for for only previously-unreported m6A peaks found in > =2 individuals in our study. g. Pearson correlation (heatmap) and hierarchical clustering (tree) of mRNA-seq profiles across the 129 GTEx samples (rows/columns) that match the individuals profiled here shows tissue-specific clustering (colors) and co-clustering of heart and muscle, as shown for m6A profiles in Fig. 1b. h. KEGG pathway enrichments for the genes harboring tissue-specific m6A.
