Extended Data Fig. 7: Posterior distribution of genetic value is well-calibrated for mixture of normal effect size distribution. | Nature Genetics

Extended Data Fig. 7: Posterior distribution of genetic value is well-calibrated for mixture of normal effect size distribution.

From: Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Extended Data Fig. 7

Each column summarizes results for each of the three genetic architectures. Small effects are simulated under pcausal = 0.01, h2g = 0.02; large effects are simulated under pcausal = 0.001, h2g = 0.02; Mixture refers to a half and half mixture of the two simulations (small effects: pcausal = 0.0005, h2g = 0.01; large effects: pcausal = 0.005, h2g = 0.01). (a) Calibration of ρ-level genetic value credible intervals. (b) Calibration of ρ-level rank credible intervals. (c) Calibration of probability of GV above threshold t. (d) Distribution of individual PRS standard deviations. See Extended Data Fig. 6 for a detailed figure description.

Back to article page