Extended Data Fig. 8: Posterior distribution of genetic value is well-calibrated with external LD. | Nature Genetics

Extended Data Fig. 8: Posterior distribution of genetic value is well-calibrated with external LD.

From: Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Extended Data Fig. 8

Each column summarizes the calibration and uncertainty of PRS trained with LD computed from four different cohorts: I. 250 K UKB training individuals; II. 2 K held-out UKBB individuals; III. 1 K held-out UKBB individuals. (a) Calibration of ρ-level genetic value credible intervals. (b) Calibration of ρ-level rank credible intervals. (c) Calibration of probability of GV above threshold t. (d) Distribution of individual PRS scaled standard deviation. See Extended Data Fig. 6 for a detailed figure description (h2g = 0.02, pcausal= 0.01).

Back to article page