Extended Data Fig. 10: Individual ranking is consistent when ranking by PRS estimates versus probability of genetic value above threshold. | Nature Genetics

Extended Data Fig. 10: Individual ranking is consistent when ranking by PRS estimates versus probability of genetic value above threshold.

From: Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Extended Data Fig. 10

The x-axis is the PRS estimates of testing individuals and the y-axis is the probability that GV is above threshold t, where t is (arbitrarily) set to the 90th percentile in the testing individuals. For the individuals whose PRS estimates are far away from threshold, the probability is 0 and 1 respectively. For individuals close to the stratification threshold, the probability of larger than the threshold increases as PRS estimates increase. The histogram on the x-axis is the distribution of PRS estimates in testing individuals and the histogram on the y-axis is its distribution in testing individuals.

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