Extended Data Fig. 3: Calibration of ρ-level genetic value credible interval with respect to proportion of causal effects and SNP-heritability in testing individuals. | Nature Genetics

Extended Data Fig. 3: Calibration of ρ-level genetic value credible interval with respect to proportion of causal effects and SNP-heritability in testing individuals.

From: Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Extended Data Fig. 3

Each row of panels corresponds to one heritability parameter \(h_g^2 \in \left\{ {0.05,0.1,0.25,0.5,0.8} \right\}\) and each column of panels corresponds to one polygenicity parameter \(p_{causal} \in \{ 0.001,0.01,0.11\}\). The x-axis is the expected coverage of ρ-GV CI (ρ). The y-axis is the empirical coverage calculated as the proportion of ρ-GV CIs that contain the true genetic value for one simulation repeat. The dots and error bars are mean ±1.96 s.e.m of the empirical coverage calculated from 10 simulation repeats.

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