Extended Data Fig. 7: Impact of AF-PRS on the age of AF onset. | Nature Genetics

Extended Data Fig. 7: Impact of AF-PRS on the age of AF onset.

From: Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction

Extended Data Fig. 7

a, Difference in the age of AF onset between individuals with high PRS (the top 1%, 5%, 10%, and 20%) and those with the remaining PRS. We constructed linear regression models by adjusting for sex and the top 20 PCs. P values were calculated by linear regression analysis comparing individuals with high PRS versus those with the remaining PRS and the significance was set at P = 8.3 × 10−3 (0.05/6). Each dot represents an estimated effect size (β) with an error bar indicating the 95% CI of the estimate obtained from the linear regression models. b, Comparison of the age of AF onset between samples with high PRS and those with remaining PRS. Box plot represents the median, the bounds represent the first and third quartile, and the whiskers reach to 1.5 times the interquartile range. In a and b, data are shown for individuals based on PRS (ntop1% = 75 vs. nremaining = 7,383; ntop5% = 373 vs. nremaining = 7,085; ntop10% = 746 vs. nremaining = 6,712; ntop20% = 1,492 vs. nremaining = 5,966).

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