Extended Data Fig. 5: Functional validation of MPRA variants.
From: Genetics of sexually dimorphic adipose distribution in humans
This plot shows luciferase activity (luciferase/Renilla) averages in 3T3-L1 preadipocytes for four technical replicates (n = 4) and average ± SEM of these four technical replicates for the control and each variant construct. Significant increase in luciferase activity between each construct and control was measured using a one-tailed paired t-test. * p < 0.05, ** p < 0.01, *** p < 0.001. Exact p-values are reported in the luciferase data available in the repository. Data are colored by MPRA significance status.
