Extended Data Fig. 6: MOFA LFs of MPM cell lines and drug response.
a) Correlations between drug responses (measured by half maximal inhibitory concentration, IC50 in μM) and MOFA LFs of cell lines. Significant associations are annotated by black point border. b) Distribution of drug response weights from the Drugs data set, with drugs for which the response is significantly correlated with the given LF annotated in black. Targeted pathways are represented in (a) by a color bar (left), and in (b) by point colors. c) Correlations between representative drug responses significantly correlated with MOFA LFs from cell lines (left: negative correlations, right: positive associations). MPM: malignant pleural mesothelioma not otherwise specified. Gray bands correspond to 95% confidence intervals. Pearson correlation coefficients and the associated two-sided P values are displayed in (a) and (c).
