Extended Data Fig. 7: Tumor burden of mutational signatures.
Tumor Mutational Burden of a) 7 copy number signatures (n = 115 biologically independent samples) and b) 10 Single Nucleotide Variant Signatures detected in the MESOMICS cohort (n = 46 biologically independent samples). Note that although SBS40 is associated with age in many cancers, its etiology is still unknown. TDP: tandem duplicator phenotype; HRD: homologous recombination deficiency; fLOH: focal loss of heterozygosity; CIN: chromosomal instability. c) Comparison of the tumor mutation burden (TMB, in number of mutations) of APOBEC signatures SBS2 and 13 in the MESOMICS cohort and in more than 2000 tumors from the Pan-Cancer Analysis of Whole Genomes (PCAWG) cohort. d) Comparison of the Relative TMB in number of somatic mutations of age-related signatures SBS1, SBS5, and SBS40, with that of APOBEC signatures SBS2 and 13 in the MESOMICS (red) and PCAWG cohorts (black).
