Extended Data Fig. 5: Subclone trees for TERT-SV, SEG-CNA and NUM-CNA patients.
From: Clonal evolution during metastatic spread in high-risk neuroblastoma
Each tree shows the subclonal structure in an individual patient. Patients are organized according to disease subtype and the availability of tumors from primary site (diagnosis/reresection/t-resection) and relapses. Branches are annotated with recurrent CNAs and oncogenic mutations/SVs and colored according to the latest tumor they were identified in 1) blue for subclones specific to a diagnostic tumor 2) light blue for subclones seen in reresections 3) green for subclones seen in a t-resection tumor 4) orange for subclones seen in a relapse tumor and 5) red for subclones seen in a further relapse tumor. Subclonal events at MYCN, TERT and ATRX loci are shown in red font. Events with which clonal status cannot be determined are indicated with a question mark. Different evolutionary patterns are indicated with an icon next to the patient id. Tumor sites and the type of sequencing are indicated below the trees. G, whole-genome sequencing. T, targeted sequencing. B, both. For H103207, H118706 and H134819 a simplified version of the tree is shown due to space. Detailed analysis of subclonal structure for 94 patients is provided in Supplementary Data Files 1–69. The data for the figures are available in Supplementary Table 5 and the scripts are available through the ISABL platform.
