Extended Data Fig. 9: Timing of metastasis.
From: Clonal evolution during metastatic spread in high-risk neuroblastoma
Signatures trees as described in Fig. 6 are shown for 13 patients with one or more tumors from the primary site and two or more tumors from locoregional and/or distant metastasis. Patients in the top row have at least one tumor from distant metastatic site while patients in the bottom row have locoregional relapses only. The subclones involved in disease spread from the primary are indicated with a black arrow while the daughter clones are shown with red arrows. The data for the figure are available in Supplementary Table 4 and the scripts are available through the ISABL platform.
