Extended Data Fig. 10: Complex seeding patterns in H132374.
From: Clonal evolution during metastatic spread in high-risk neuroblastoma
Subclonal structure for patient H132374 is shown with treatment timeline and signature tree as described in Figs. 4a and 6, respectively. Body maps depict two different scenarios that explain the subclonal structure in H132374: The left body map shows possible polyclonal seeding in the CNS by a mixture of subclones 3 and 4. In this scenario lung metastasis is caused by subclone-4 after platinum chemotherapy. Shown on the right body map is the second scenario of met-to-met seeding from CNS to lung by subclone-4 after therapy. Detailed description of the patient is provided in Supplementary Information and Supplementary Data File 19. The data for the figure are available in Supplementary Table 4 and as raw data at dbGAP and scripts are available through ISABL platform.
