Extended Data Fig. 2: Identification of factors explaining donor variability in snATAC-seq data.
(a,d,g,j) Absolute Spearman correlation coefficient between the first 6 principle components (PCs) and each biological or technical variable in beta (a), alpha (d), delta (g), and gamma (j) cells. An absolute Spearman correlation threshold of 0.4 was used to identify factors having a high correlation with each PC. (b,e,h,k) Principal component analysis (PCA) based on cCREs in beta (b), alpha (e), delta (h), and gamma (k) cells from individual non-diabetic (n = 11), pre-T2D (n = 8), and T2D (n = 15) donors which are color-coded by disease status. Each donor in the space is defined by the first two principal components (left) and the two principal components (right) that show highest correlation with disease status. (c,f,i,l) Pairwise Spearman correlation coefficients between biological or technical variables in beta (c), alpha (f), delta (i), and gamma (l) cells.
