Fig. 7: Additive effects between CHRNB2 rare variants and smoking PGS.
From: Rare coding variants in CHRNB2 reduce the likelihood of smoking
Prevalence estimates of heavy smokers among CHRNB2 rare variant carriers and non-carriers within each of the five PGS quintiles in the UKB are plotted. Standard errors of the prevalence estimates, displayed as error bars, were calculated using the formula √(pq/n), where n is the number of individuals in each group, p is the prevalence of heavy smoker in the group and q is 1 − p. The PGS was based on a GWAS meta-analysis of the ever smoker phenotype (Methods). CHRNB2 rare variants are those that were aggregated into the CHRNB2 pLOF-plus-missense (AAF < 0.001) burden mask. Statistical differences in the prevalence between carriers and non-carriers were tested using a logistic regression analysis within each quintile; ORs, 95% CIs and P values are shown.
