Fig. 4: Classification of POAG loci into VCDR- or IOP-specific SNPs.
From: Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
a, Plot shows hierarchical clustering of 263 MTAG POAG loci (a multitrait colocalization approach is shown in Extended Data Fig. 6). Based on the z scores (dashed line shows y = x where the z scores of VCDR and IOP are equal), there is a subset of SNPs that act primarily via IOP (n = 171, dots) and a subset of SNPs acting primarily via VCDR (n = 92, squares). b, Plot displays the effect sizes on VCDR and on POAG for the 92 VCDR-specific SNPs. c, Plot displays the effect sizes on IOP and on POAG for the 171 IOP-specific SNPs. The dots show the effect sizes of SNPs, and the error bars show the 95% confidence interval of the estimations of SNP effect sizes.
