Extended Data Fig. 3: Quantile-quantile plots for POAG GWAS.
From: Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci
a, Quantile-quantile plot for multi-trait POAG GWAS in participants of European ancestry. The quantile-quantile plot is based on one million randomly selected SNPs. Linkage disequilibrium (LD) score regression intercept is used to assess the genomic inflation; the intercept is 0.957 (standard error = 0.013, attenuation ratio < 0), and the lambda value is 1.27. b, Quantile-quantile plot for POAG multi-ancestry meta-analysis. The lambda value is 1.28. Because of the multi-ancestry design, LDSC was not performed.
