Fig. 3: Deterioration of glucose homeostasis progressing into T2D and leading to complications in multiple organs and tissues. | Nature Genetics

Fig. 3: Deterioration of glucose homeostasis progressing into T2D and leading to complications in multiple organs and tissues.

From: GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Fig. 3

Established (left, in peach) and new (right, in green). a, A human figure illustrating the main causes of hyperglycemia (a combination of lifestyle and genetic factors), and how hyperglycemia affects many organs and tissues. Complications on the left panel are well-established for T2D. Those on the right panel are emerging ones and are supported by our current analyses. Figure created with BioRender.com. b, DEPICT prioritization of 134 tissues from the GTEx Project highlights the ileum and pancreas (shown in red, one-sided empirical P value with FDR < 0.05 determined against randomized phenotypes in a null GWAS).

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