Extended Data Fig. 2: Validation of the effects of individual CF-KOs.
From: In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis
(a-b) Heatmap showing changes in representative populations for each CF-KO compared to a Non-Targeting Control (Fold-change in population abundances versus NTC) under lineage-priming (a) and Myeloid differentiation and terminal Myeloid maturation (b). The Myeloid master regulator Pu.1 (Spi1) was included as a positive control. Gates and values for the selected populations are derived from Supplementary Fig. 2c, d. (c-d) Exemplar FACS plots showing validation results for individual CF-KOs under lineage priming conditions (c) and Terminal Myeloid Differentiation (d). These validations were performed in different batches. Each batch included a Non-Targeting Control condition. All results were compared with the NTC included in each batch.
