Extended Data Fig. 3: The enrichment of cis- and trans-colocalizations in EA-specific colocalizations and functional states.

a, Enrichment of trans- vs cis-mQTLs amongst EA-specific colocalizations vs others in NSPT (left), and amongst EA-specific vs EAS-EUR shared colocalizations (right). Trans-, cis- colocalizations in East Asian is carried out based on mQTLs in NSPT (N = 3,523) and 107 GWASs in BBJ (N = ~170,000). Trans-, cis-colocalization in European is carried out based on mQTLs in GoDMC (N = 27,750) and 107 GWAS traits in UKBB (N = ~500,000) which are overlapped with traits in BBJ. b, Enrichment results of cis- vs trans-colocalization loci in functional elements. Left: enrichment of cis- and trans-colocalization loci in functional elements; Middle, enrichment of East Asian-specific and EAS-EUR shared cis-colocalization loci in functional elements; Right, enrichment of East Asian-specific and EAS-EUR shared trans-colocalization loci in functional elements. c, Enrichment of cis- and trans-colocalization loci in chromatin states. Left, enrichment of cis- and trans-colocalization loci in chromatin states; Middle, enrichment of East Asian-specific and EAS-EUR shared cis-colocalization signals in chromatin states; Right, enrichment of East Asian-specific and EAS-EUR shared trans-colocalization signals in chromatin states. Two-tailed Fisher’s exact test is applied. Each point with an error bar indicates log₁₀-scaled odds ratio and its 95% confidence interval.