Fig. 3: Imputation with AutoComplete increases GWAS power. | Nature Genetics

Fig. 3: Imputation with AutoComplete increases GWAS power.

From: Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries

Fig. 3

Results of GWAS of the observed portions of bilirubin, LifetimeMDD and cannabis ever taken in the UKBB (indicated as Obs), where each phenotype had 21%, 80% and 67% missingness respectively. GWAS was then performed for all individuals in the dataset after using AutoComplete to impute the missing entries for each phenotype (indicated as ImpAll). The significance threshold of \(P < 5\times 1{0}^{-8}\) is indicated by a red line, and SNPs passing the threshold are highlighted in red.

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