Fig. 2: Manhattan plots of the meta-analysis results across 2,525,730 participants.
From: Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
a, Random-effects model test. b, MR-MEGA meta-regression test (chi-squared test with df = 4). The x axis shows chromosome and base pair positions of each variant tested in the meta-analyses. The y axis shows the two-sided P value with no multiple-test correction in the −log10 scale. Orange horizontal dashed line indicates the Bonferroni-adjusted significant threshold of P < 5 × 10−9. Gray horizontal dashed line indicates the truncation line, where all −log10 P values greater than 40 were truncated to 40 for visual clarity. Novel loci are highlighted in red and annotated with the nearest protein coding gene.
