Fig. 3: Heterogeneity upset plots.
From: Multi-ancestry genome-wide association meta-analysis of Parkinson’s disease
a, Top variants per novel loci. b, Top variants per MR-MEGA identified locus with moderate to high heterogeneity (I2 > 30). The top bar plot illustrates heterogeneity with dark blue indicating ancestry heterogeneity proportion and light blue indicating other residual heterogeneity proportion. The bottom plot shows the subcohort level beta values with blue indicating positive and red indicating negative effect directions. Three variants with greater than 30% I2 total heterogeneity were only identified in the MR-MEGA meta-analysis method, whereas little to no heterogeneity is observed in loci identified in random effect.
