Extended Data Fig. 7: Association of the GPS-DOE with drug indication in the Open Target dataset.
From: Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications
For GPS-DOE, the association of the increasing absolute values of the GPS-DOE with drug indications was investigated by binning the Open Target drug dataset (n = 839,752 independent drug-gene-phenotype combinations) into 0.3 increments of the GPS-DOE and comparing scores greater or equal to each increment with scores equal to zero. For each bin, a logistic regression model was performed with drug indication as the outcome variable and the GPS-DOE bin as the predictor variable, adjusting for phecode categories as covariates and the number of gene targets per drug binarized into drugs with a single gene target and drugs with multiple gene targets. ORs with 95% CI are defined in the forest plot as circles and error bars and we repeated the associations for GPS-DOE restricted to LOF predictions and GOF predictions only.
